The graphical user interface of ADDPLAN 5 MC was consistently developed according to modern Microsoft® Windows software. Some of the new features of ADDPLAN MC (which is fully integrated in the ADDPLAN package) are

• Specific options for performing multi-armed designs including treatment arm selection
  • Confirmatory analysis for multi-armed trial with selection of treatment arms
  • Closed testing procedure (CTP)
  • Powerful simulation engine for performing multiarmed designs
  • Assess the power and ASN of adaptive designs
  • Choice of intersection tests: Dunnett, Bonferroni, Sidák, Simes, hierarchical testing
  • Comparison of selection rules
  • Comparison of dose-response shapes, e.g., linear, logistic, Emax, sigmoid Emax, exponential,...
  • Sample size reassessment procedures for multi-armed designs
  • Different sample size allocation over treatment arms
  • Multiplicity adjusted confidence intervals for many to one comparisons
  • Overall multiplicity adjusted p-values
• Extensive choice of graphical illustration of simulation and study results
• Planning, simulation, and analysis runs are completely separated in tabs
• XML file storing system
• File versions audit trail
• Fully integrated adaptive and classical designs capabilities